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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SOS2
All Species:
26.36
Human Site:
Y486
Identified Species:
58
UniProt:
Q07890
Number Species:
10
Phosphosite Substitution
Charge Score:
0.1
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q07890
NP_008870.2
1332
152979
Y486
P
G
Y
S
S
A
E
Y
R
L
K
E
K
F
V
Chimpanzee
Pan troglodytes
XP_515425
1598
179688
Y753
P
G
A
S
N
A
E
Y
R
L
K
E
K
F
F
Rhesus Macaque
Macaca mulatta
XP_001099864
1331
152695
Y486
P
G
Y
S
S
A
E
Y
R
L
K
E
K
F
V
Dog
Lupus familis
XP_547804
1363
156214
Y517
P
G
Y
S
N
A
E
Y
R
L
K
E
K
F
I
Cat
Felis silvestris
Mouse
Mus musculus
Q02384
1333
153108
Y487
P
G
Y
S
S
A
E
Y
R
L
K
E
K
F
V
Rat
Rattus norvegicus
NP_001129033
1333
153157
Y487
P
G
Y
S
S
A
E
Y
R
L
K
E
K
F
V
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001515100
1332
152934
F486
P
G
Y
S
S
A
E
F
R
L
K
E
K
F
I
Chicken
Gallus gallus
XP_421461
1466
167231
Y622
P
G
Y
S
N
A
E
Y
R
L
K
E
K
I
I
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_690171
1343
153249
F483
G
A
G
S
G
A
E
F
R
L
K
E
K
F
V
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P26675
1596
177916
D529
S
A
G
A
T
A
Y
D
Y
R
L
K
E
K
Y
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_782335
1310
150821
F487
S
S
S
P
E
Y
R
F
K
E
R
Y
Y
L
R
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
58.7
99
93.2
N.A.
94.9
94.6
N.A.
91.1
78.9
N.A.
73
N.A.
39.8
N.A.
N.A.
52.1
Protein Similarity:
100
68.5
99.7
95.5
N.A.
97.9
97.4
N.A.
95.9
84.7
N.A.
83.9
N.A.
55.1
N.A.
N.A.
68
P-Site Identity:
100
80
100
86.6
N.A.
100
100
N.A.
86.6
80
N.A.
66.6
N.A.
6.6
N.A.
N.A.
0
P-Site Similarity:
100
86.6
100
100
N.A.
100
100
N.A.
100
93.3
N.A.
73.3
N.A.
33.3
N.A.
N.A.
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
19
10
10
0
91
0
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
10
0
0
0
0
0
0
0
% D
% Glu:
0
0
0
0
10
0
82
0
0
10
0
82
10
0
0
% E
% Phe:
0
0
0
0
0
0
0
28
0
0
0
0
0
73
10
% F
% Gly:
10
73
19
0
10
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
0
0
10
28
% I
% Lys:
0
0
0
0
0
0
0
0
10
0
82
10
82
10
0
% K
% Leu:
0
0
0
0
0
0
0
0
0
82
10
0
0
10
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
28
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
73
0
0
10
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
10
0
82
10
10
0
0
0
10
% R
% Ser:
19
10
10
82
46
0
0
0
0
0
0
0
0
0
0
% S
% Thr:
0
0
0
0
10
0
0
0
0
0
0
0
0
0
0
% T
% Val:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
46
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
64
0
0
10
10
64
10
0
0
10
10
0
10
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _